Biotin and derivatives
Medchemexpress LLC Mal-PEG24-NHS ester | 2226733-37-3 | MFCD11041160 | 95.0% | C62H111N3O31 | 10MG
Mal-PEG24-NHS ester is a polyethylene glycol (PEG)-based bifunctional linker bearing a maleimide and an N-hydroxysuccinimide (NHS) ester. It enables thiol-to-maleimide and amine-to-NHS conjugation for assembly of PROTACs and other bioconjugates; supplied as a colorless to light-yellow oil with high purity and good aqueous solubility.
- Enables thiol and amine conjugation via maleimide and NHS ester chemistry.
- Long PEG24 spacer increases solubility and reduces steric hindrance.
- High purity supports reliable reaction performance.
- High aqueous solubility simplifies handling and formulation.
- Suitable for PROTAC synthesis and general bioconjugation workflows.
Chem-Impex International, Inc. Biotin-N-hydroxysuccinimide | 35013-72-0 | MFCD00078531 | 5G
Biotin-N-hydroxysuccinimide, 35013-72-0, MFCD00078531, 5G
Medchemexpress LLC Biotin-PEG6-NHS ester | 2055045-04-8 | 98.0% | C29H48N4O12S | 25 MG
Biotin-PEG6-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Enables targeted protein degradation via the ubiquitin-proteasome system
- Connects ligands for E3 ubiquitin ligase and target proteins
TARGETMOL CHEMICALS INC NSP-SA-NHS 5MG
Also available in 1 mg, 10 mg, 25 mg, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. NSP-SA-NHS is a chemiluminescent acridinium ester that can be used for immunoassays. Purity 98.42%
Medchemexpress LLC M-PEG14-NHS ester | 00-00-0 | 95.0% | 773.86 g/mol | C34H63NO18 | 5 MG
m-PEG14-NHS ester is a methoxy-terminated polyethylene glycol linker bearing an N-hydroxysuccinimide (NHS) ester functional group. It is designed for amine-reactive conjugation in the synthesis of proteolysis targeting chimeras (PROTACs) and related bioconjugation workflows, supplied as a white to off-white solid for research use only.
- Provides an m-PEG14 spacer for flexible linker length
- NHS ester enables efficient coupling to primary amines
- High purity suitable for synthetic applications
- Offered in small quantities for laboratory-scale synthesis
- Stable when stored sealed at low temperature and protected from moisture
Medchemexpress LLC Bz-(Me)Tz-NHS | 1454558-58-7 | MFCD00076258 | C₁₉H₂₀N₅O₅S | 25 MG
Bz-(Me)Tz-NHS is a click chemistry reagent that contains a methyltetrazine group. It functions as a 3rd generation Click-Linker for Cu-free click conjugation, primarily used in antibody-drug conjugate (ADC) related research.
- Contains a methyltetrazine group
- Functions as a 3rd generation Click-Linker
- Designed for Cu-free click conjugation
- Used in antibody-drug conjugate (ADC) related research
Medchemexpress LLC Bis-PEG9-NHS ester 250mg | 1008402-79-6 | 250 MG
Bis-PEG9-NHS ester is a homobifunctional polyethylene glycol (PEG) linker bearing two N-hydroxysuccinimide (NHS) ester reactive groups, used for amine-directed bioconjugation in the synthesis of PROTACs and antibody-drug conjugates. The PEG9 spacer increases hydrophilicity to improve solubility and reduce steric hindrance during conjugation.
- Contains two NHS ester reactive groups for amine coupling.
- PEG9 spacer increases hydrophilicity and solubility in aqueous media.
- High purity (≥98.0%) suitable for research and conjugation chemistry.
- Molecular weight 708.71 g/mol and chemical formula C30H48N2O17.
- Viscous, colorless to light yellow appearance for easy handling.
- Applicable to protein labeling, bioconjugation, and linker synthesis.
Medchemexpress LLC Mal-PEG8-NHS ester | 2055033-05-9 | 99.0% | 1 G
Mal-PEG8-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. They exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
- Molecular weight: 618.63
- Molecular formula: C27H42N2O14
- Purity: 98.96%
- Appearance: Colorless to light yellow viscous liquid
- Soluble in DMSO: ≥ 100 mg/mL
Medchemexpress LLC Mal-PEG2-NHS ester | 1433997-01-3 | 98.6% | 354.31 g/mol | C15H18N2O8 | 1 G
Mal-PEG2-NHS ester is a non-cleavable ADC linker combining a maleimide reactive group, a two-unit polyethylene glycol spacer, and an N-hydroxysuccinimide (NHS) ester for amine coupling. It is supplied as a purified reagent for bioconjugation and linker chemistry applications.
- Non-cleavable maleimide-NHS bifunctional linker
- PEG2 spacer improves solubility and reduces steric hindrance
- NHS ester enables efficient coupling to primary amines
- Maleimide group enables thiol-selective conjugation
- High purity suitable for ADC synthesis and bioconjugation
Medchemexpress LLC Azido-PEG8-NHS ester | 1204834-00-3 | 99.5% | 564.58 g/mol | C23H40N4O12 | 50 MG
Azido-PEG8-NHS ester is an azide-functional PEG8 N-hydroxysuccinimide (NHS) ester used as a cleavable linker and bioconjugation reagent for click chemistry and the synthesis of antibody-drug conjugates and PROTAC linkers. It is supplied as a colorless to light yellow liquid with high purity and is intended for research use.
- Azide functionality enables copper-catalyzed and strain-promoted click reactions.
- Peg8 spacer increases hydrophilicity and reduces steric hindrance.
- NHS ester readily reacts with primary amines for bioconjugation.
- High reported purity suitable for synthetic and bioconjugation workflows.
- Storage stability: stable as a pure compound at -20°C for up to 3 years.
- Solubility: soluble in DMSO (100 mg/mL); ultrasonic agitation may be required.
eMolecules Mal-PEG11-alcohol | Broadpharm |581.656 | C26H47NO13 | 98.000 | OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN1C(=O)C=CC1=O | 1g | 599128887
Mal-PEG11-alcohol | Broadpharm |581.656 | C26H47NO13 | 98.000 | OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN1C(=O)C=CC1=O | 1g | 599128887
Medchemexpress LLC Azido-PEG3-NHS ester | 1092654-47-1 | ≥98.0% | C12H18N4O7 | 250 MG
Azido-PEG3-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, capable of participating in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules, and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. This compound is integral in the development of PROTACs, which harness the ubiquitin-proteasome system to selectively degrade target proteins.
- Peg-based protac linker
- Used in the synthesis of protacs
- Click chemistry reagent
- Contains an azide group
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Engages in strain-promoted alkyne-azide cycloaddition (SPAAC)
- Enables selective degradation of target proteins
Medchemexpress LLC Azido-PEG4-NHS-ester | 1807534-82-2 | 96.0% | C14H22N4O8 | 25 MG
Azido-PEG4-NHS-ester is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. It functions as a click chemistry reagent.
- Functions as a click chemistry reagent
- Contains an azide group for chemical reactions
- Engages in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions
- Participates in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
- Viscous liquid appearance
- Colorless to light yellow color